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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
BPS-78190 | 1 ml (500 µl x 2) | - | - |
3 - 15 business days* |
1,166.00€
|
The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells,... more
Product information "PD-1 (Human) sgRNA-MS2 Lentivirus (Integrating)"
The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells, to its ligands PD-L1 and PD-L2, negatively regulates immune responses. PD-1 ligands are found on most cancers, and the PD-1:PD-L1/2 interaction inhibits T-cell activity and enables cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes. The PD-1 sgRNA-MS2 Lentiviruses are replication incompetent, HIV-based VSV-G pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. The particles contain 5 sgRNA-MS2 (single guide RNA fused with an MS2 tag). When transduced in cells expressing dCas9-VP64 and MS2-P65-HSF1, these other proteins are recruited to the site in the genomic DNA that is targeted by the sgRNA and begin transcription, inducing expression of PD-1.
Keywords: | hPD-1, CD279, Protein PD-1, Programmed cell death protein 1, |
Supplier: | BPS Bioscience |
Supplier-Nr: | 78190 |
Properties
Application: | CRISPR studies |
Species reactivity: | human |
Database Information
KEGG ID : | K06744 | Matching products |
UniProt ID : | Q15116 | Matching products |
Gene ID | GeneID 5133 | Matching products |
Handling & Safety
Storage: | -80°C (-70 °C for long term storage) |
Shipping: | -80°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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