PD-1 (Human) sgRNA-MS2 Lentivirus (Integrating)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
BPS-78190 1 ml (500 µl x 2) - -

3 - 15 business days*

998.00€
 
The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells,... more
Product information "PD-1 (Human) sgRNA-MS2 Lentivirus (Integrating)"
The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated T-cells, to its ligands PD-L1 and PD-L2, negatively regulates immune responses. PD-1 ligands are found on most cancers, and the PD-1:PD-L1/2 interaction inhibits T-cell activity and enables cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes. The PD-1 sgRNA-MS2 Lentiviruses are replication incompetent, HIV-based VSV-G pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. The particles contain 5 sgRNA-MS2 (single guide RNA fused with an MS2 tag).  When transduced in cells expressing dCas9-VP64 and MS2-P65-HSF1, these other proteins are recruited to the site in the genomic DNA that is targeted by the sgRNA and begin transcription, inducing expression of PD-1.
Keywords: hPD-1, CD279, Protein PD-1, Programmed cell death protein 1,
Supplier: BPS Bioscience
Supplier-Nr: 78190

Properties

Application: CRISPR studies
Reactivity: Human

Handling & Safety

Storage: -80°C (-70 °C for long term storage)
Shipping: -80°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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