FCGR2A (Human) CRISPR/Cas9 Lentivirus (Integrating)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
BPS-78207 1 ml (500 µl x 2) - -

3 - 15 business days*

998.00€
 
FCGR2A1 (Low Affinity Fc Gamma Receptor IIa (FcgammaRIIa), also known as CD32a) encodes one... more
Product information "FCGR2A (Human) CRISPR/Cas9 Lentivirus (Integrating)"
FCGR2A1 (Low Affinity Fc Gamma Receptor IIa (FcgammaRIIa), also known as CD32a) encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells such as macrophages and neutrophils. It is involved in the process of phagocytosis and clearing immune complexes. FCGR2A is involved in activating cellular responses, while FCGR2B is inhibitory, and the balance between these receptors regulates immune activation and tolerance. The FCGR2A CRISPR Lentiviruses are replication incompetent, HIV-based VSV-G pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a CRISPR/Cas9 gene driven by an EF1a promoter, along with 5 sgRNA (single guide RNA) targeting human FCGR2A driven by a U6 promoter (Figures 1 and 2). The integrating lentivirus integrates randomly into the cellular genome to express both Cas9 and the sgRNA. Puromycin selection forces high expression levels of both Cas9 and the sgRNA, and can be used with the integrating lentivirus to quickly and easily achieve high knockdown efficiencies in a cell pool. Efficiencies may vary, depending on the cell type and the gene of interest.
Keywords: CD32, CDw32, FCGR2A, FcRII-a, Fc-gamma-RIIa, Fc-gamma RII-a, IgG Fc receptor II-a, Low affinity immunoglobulin gamma Fc region receptor II-a,
Supplier: BPS Bioscience
Supplier-Nr: 78207

Properties

Application: CRISPR studies
Reactivity: Human

Handling & Safety

Storage: -80°C (-70 °C for long term storage)
Shipping: -80°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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