PD-L1 (human) ELISA Kit

PD-L1 (human) ELISA Kit
Item number Size Datasheet Manual SDS Delivery time Quantity Price
AG-45B-0016-KI01 96 wells -

3 - 9 business days

605.00€
 
ELISA Assay. Detects soluble human PD-L1 (sPD-L1) in serum, plasma and cell culture supernatant..... more
Product information "PD-L1 (human) ELISA Kit"
ELISA Assay. Detects soluble human PD-L1 (sPD-L1) in serum, plasma and cell culture supernatant.. Assay Type: Sandwich. Sample Type: Cell Culture Supernatant,Plasma,Serum. Range: 2.34 to 150pg/ml. Sensitivity: 0.8pg/ml. PD-L1 (also known as Programmed Cell Death 1 Ligand Protein 1, CD274 or B7-H1) is an immuno-coinhibitory member of the B7 family and functions as an immune checkpoint via its interaction with its receptors PD-1 (CD279) and CD80 (also known as B7-1). PD-L1 is expressed by hematopoietic cells such as T, B and dendritic cells and by parenchymal cells in response to cytokine (i.e. IFN-gamma) induction. Ligation of PD-1 by PD-L1 (B7-H1, CD274) or PD-L2 (B7-DC, CD273) inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma and also inhibits BCR mediated signaling. PD-L1 binding to CD80 inhibits T cells proliferation. PD-1 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases. Soluble form of PD-L1 (sPD-L1) is expressed upon immune cells activation and can be secreted in the serum/plasma. Soluble checkpoints, such as sPD-1 or sPD-L1, are involved in positive or negative immune regulation and changes in their serum/plasma levels affect the development, prognosis and treatment of cancer. Increase of sPD-L1 or sPD-1 levels have been detected in patients with different types of cancer. This PD-L1 (human) ELISA kit is developed to detect specifically sPD-L1 (human) in different biological fluids.
Keywords: Programmed Cell Death 1 Ligand Protein 1, PDCD1 Ligand 1, B7-H1, PDL1, CD274
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-45B-0016-KI01

Properties

Reactivity: Human
Format: Solid

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
GHS Hazard Pictograms:
H Phrases: H314
Caution
Our products are for laboratory research use only: Not for administration to humans!
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