Mouse 12-LO (Arachidonate 12-Lipoxygenase) ELISA Kit

Mouse 12-LO (Arachidonate 12-Lipoxygenase) ELISA Kit
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Item number Size Datasheet Manual SDS Delivery time Quantity Price
G-MOES01636.96 96 assays - -

9 - 20 business days

576.00€
 
ELISA Type: Sandwich. Sensitivity: 0.469ng/mL. Range: 0.781--50ng/mL. Protein function: Catalyzes... more
Product information "Mouse 12-LO (Arachidonate 12-Lipoxygenase) ELISA Kit"
ELISA Type: Sandwich. Sensitivity: 0.469ng/mL. Range: 0.781--50ng/mL. Protein function: Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:8188678, PubMed:11256953, PubMed:25293588). Mainly converts arachidonic acid to (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid (PubMed:8188678, PubMed:11256953). In contrast does not react towards methyl esters of linoleic and arachidonic acids (PubMed:11256953). Also catalyzes the epoxidation of double bonds of polyunsaturated fatty acids such as 14S-hydroperoxy-docosahexaenoate (DHA) resulting in the formation of (13S,14S)-epoxy-DHA. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation (PubMed:9501222). It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation. [The UniProt Consortium]
Keywords: P-12LO, Alox12, 12S-LOX, Alox12p, EC=3.3.2.-, 12S-lipoxygenase, Lipoxin synthase 12-LO, Linoleate 13S-lipoxygenase, Platelet-type lipoxygenase 12, Arachidonate 15-lipoxygenase,15S-type, Arachidonate 12-lipoxygenase, 12S-type
Supplier: ELISA Genie
Supplier-Nr: MOES01636

Properties

Application: Sandwich ELISA
Reactivity: Mouse
Format: Solid Phase

Handling & Safety

Storage: vT
Shipping: +4°C (International: +4°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319
P Phrases: P264, P280
Caution
Our products are for laboratory research use only: Not for administration to humans!
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