Interleukin-1alpha (human) ELISA Kit

Interleukin-1 (IL-1) is a name for a family of proteins which include IL-alpha, IL-1beta, ILra (interleukin receptor antagonist), and IL-18. IL-1alpha is synthesized as a 33 kDa (271 amino acid) pro-cytokine that is enzymatically cleaved by calpain into the active 159 amino acid, 17 kDa peptide. IL-1alpha is produced by many cells types including macrophages, monocytes, astrocytes, keratinocytes, adipocytes, T-cells, and eosinophils. Although IL-1alpha and IL-1beta exhibit only 26% amino acid identity, they bind to the same cell-surface receptors, IL-1 RI and IL-1 RII, present on a variety of cell types involved in immune or inflammatory responses. Normal production of IL-1 is critical for mediating host responses to infection and injury. Disease states in which IL-1 actively participates include inflammatory diseases such as arthritis, inflammatory bowel disease, and shock, as well as atherosclerosis, allergy, and some types of cancer. Cayman's IL-1alpha (human) ELISA Kit is an immunometric (i.e., sandwich) ELISA that permits IL-1alpha measurements within the range of 3.9-250 pg/ml, typically with a limit of detection of 3.9 pg/ml.Synonyms: IL-1alpha (human) EIA Kit. Limit of Detection: 3.9 pg/ml. Assay Range: 3.9-250 pg/ml. Cross Reactivity: (Interleukin-1alpha) 100%, (Interleukin-1beta) <0.01%, (Interleukin-2) <0.01%. Origin: Animal/Mouse, Animal/Bovine.