Human TNF-alpha (Tumor Necrosis Factor Alpha) ELISA Kit

Human TNF-alpha (Tumor Necrosis Factor Alpha) ELISA Kit
Item number Size Datasheet Manual SDS Delivery time Quantity Price
G-HUES01395.96 96 assays -

9 - 20 business days*

534.00€
 
ELISA Type: Sandwich. Sensitivity: 4.688 pg/mL. Range: 7.813--500 pg/mL. Protein function:... more
Product information "Human TNF-alpha (Tumor Necrosis Factor Alpha) ELISA Kit"
ELISA Type: Sandwich. Sensitivity: 4.688 pg/mL. Range: 7.813--500 pg/mL. Protein function: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T- cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918, PubMed:16829952, PubMed:23396208). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance. [The UniProt Consortium]
Keywords: TNF, TNFA
Supplier: Assay Genie
Supplier-Nr: HUES01395

Properties

Application: Sandwich ELISA
Species reactivity: human
Format: Solid Phase

Handling & Safety

Storage: vT
Shipping: +4°C (International: +4°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319
P Phrases: P264, P280
Caution
Our products are for laboratory research use only: Not for administration to humans!
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