Human PADI4 (Peptidyl Arginine Deiminase Type IV) ELISA Kit

Human PADI4 (Peptidyl Arginine Deiminase Type IV) ELISA Kit
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-EL-H1322.96 96 wells -

7 - 16 business days*

483.00€
 
The kit is a Sandwich enzyme immunoassay for in vitro quantitative measurement of PADI4 in serum,... more
Product information "Human PADI4 (Peptidyl Arginine Deiminase Type IV) ELISA Kit"
The kit is a Sandwich enzyme immunoassay for in vitro quantitative measurement of PADI4 in serum, plasma and other biological fluids. Detection Range: 0.19--12ng/mL. Sensitivity: 0.11ng/mL. Protein function: Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg- 54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1. [The UniProt Consortium]
Keywords: PAD4, PADI4, HL-60 PAD, EC=3.5.3.15, Peptidylarginine deiminase IV, Protein-arginine deiminase type-4, Protein-arginine deiminase type IV
Supplier: Elabscience
Supplier-Nr: E-EL-H1322

Properties

Application: ELISA
Species reactivity: human
Format: Solid Phase

Handling & Safety

Storage: vT
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Human PADI4 (Peptidyl Arginine Deiminase Type IV) ELISA Kit"
Write a review
or to review a product.
Viewed