Reporter Assays

INDIGO's panel of RXR reporter assays utilizes non-human mammalian cells engineered to individually express human retinoic acid receptors, RXRalpha (NR2B1), RXRbeta (NR2B2), or RXRgamma (NR2B3). INDIGO's RXR reporter cells include the luciferase reporter gene functionally linked to a responsive promoter. Thus,...

This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of human constitutive androstane receptor, isoform 3 (NR1I3), a ligand-dependent transcription factor commonly referred to as CAR3. These reporter cells utilize a modified...

This nuclear receptor assay system utilizes proprietary human cells engineered to provide constitutive, high-level expression of the human thyroid hormone receptor alpha (NR1A1), a ligand-dependent transcription factor commonly referred to as TRalpha. INDIGO's reporter cells include the luciferase reporter gene...

This nuclear receptor assay system utilizes proprietary human cells engineered to provide constitutive, high-level expression of the human thyroid hormone receptor beta (NR1A2), a ligand-dependent transcription factor commonly referred to as TRbeta. INDIGO's reporter cells include the luciferase reporter gene...

INDIGO's panel of TR reporter assays utilizes non-human mammalian cells engineered to express human thyroid hormone receptors alpha (NR1A3) and beta (NR1A2), ligand-dependent transcription factors commonly referred to as TRalpha and TRbeta. INDIGO's TR reporter cells include the luciferase reporter gene functionally...

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor gamma (NR1B3), a ligand-dependent transcription factor commonly referred to as RARG or RARgamma. INDIGO's reporter cells include the luciferase...

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor, beta (NR1B2), a ligand-dependent transcription factor commonly referred to as RARB or RARbeta. INDIGO's reporter cells include the luciferase reporter...

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human retinoic acid receptor, alpha (NR1B1), a ligand-dependent transcription factor commonly referred to as RARA or RARalpha. INDIGO's reporter cells include the luciferase...

INDIGO's panel of RAR reporter assays utilizes non-human mammalian cells engineered to individually express human retinoic acid receptors, RARalpha (NR1B1), RARbeta (NR1B2), or RARgamma (NR1B3). INDIGO's RAR reporter cells include the luciferase reporter gene functionally linked to a responsive promoter. Thus,...

This human RAR-related orphan receptor gamma (RORgamma) mRNA is expressed from the RORC gene in two forms via alternate usage of tissue-specific promoters. Variant 1 mRNA is expressed in numerous tissues, and encodes receptor isoform 1, referred to as RORgamma. Variant 2 mRNA comprises an alternate exon 1 that...

This nuclear receptor assay system utilizes proprietary human mammalian cells engineered to provide high-level expression of a hybrid form of the human estrogen-related receptor alpha (NR3B1). The N-terminal DNA binding domains (DBD) of the native ERRalpha has been substituted with that of the yeast GAL4-DBD. The...

This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide high-level expression of a hybrid form of the Human Estrogen-Related Receptor gamma (NR3B3). The N-terminal DNA binding domains (DBD) of the native ERRgamma has been substituted with that of the yeast GAL4-DBD....