Anti-phospho-Tau, (Ser409) (Tau Protein, Microtubule-associated Protein, MAP)

Anti-phospho-Tau, (Ser409) (Tau Protein, Microtubule-associated Protein, MAP)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
T1032-72B.40 40 µg - -

3 - 19 business days*

419.00€
 
Tau is a microtubule-associated phosphoprotein (MAP) localized in neuronal axons. That promotes... more
Product information "Anti-phospho-Tau, (Ser409) (Tau Protein, Microtubule-associated Protein, MAP)"
Tau is a microtubule-associated phosphoprotein (MAP) localized in neuronal axons. That promotes tubulin polymerization and microtubules stabilization. Tau proteins constitute a family of six isoforms ranging from 352 to 441 amino acids. The tau variants differ from each other by the presence of either three or four repeated regions in the carboxyl terminal of the molecule and the absence or presence of one or two inserts in the portion ofamino-terminal. , Tau is hyperphosphorylated by ERK, GSK-3, TPKII, and CDK5. At least thirty phosphorylation sites have been described including Thr39, Ser46, Thr50, Thr69, Thr153, Thr175, Thr181, Ser198, Ser199, Ser202, Thr205, Ser208, Ser210, Thr212, Ser214, Thr217, Thr231, Ser235, Ser237, Ser241, Ser262, Ser285, Ser305, Ser324, Ser352, Ser356, Ser396, Ser400, Thr403, Ser404, Ser409, Ser412, Ser413, Ser416, and Ser422. Specifically, TPKII phosphorylates serines 202 and 404. GSK-3beta transfection phosphorylates serines 199, 202, 235, 396, 404, and 413, and threonines 205 and 231. These sites are among the major atypical phosphorylation sites of tau. Phosphorylation on these sites reduces the ability of a given tau species to promote microtubule self-assembly. Hyperphosphorylated tau is the major protein of the paired helical filaments (PHFs) which make up the pathological neurofibrillary tangles of Alzheimer's disease (AD). PHFs are also found in the lesions of other central nervous system disorders. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 0.05-0.2ug/ml, Western Blot: 0.5-2ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplier: United States Biological
Supplier-Nr: T1032-72B

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Synthetic phospho-peptide (KLH). corresponding to residues surrounding phospho-serine 409 of human tau.
Purity: Purified by Affinity chromatography.
Format: Affinity Purified

Database Information

Handling & Safety

Storage: -20°C (-20°C Glycerol)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-phospho-Tau, (Ser409) (Tau Protein, Microtubule-associated Protein, MAP)"
Write a review
or to review a product.
Viewed