Anti-phospho-Tau, (Ser396) (PHF13)

Anti-phospho-Tau, (Ser396) (PHF13)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
T1040-02G.100 100 µl - -

3 - 19 business days*

554.00€
 
Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule... more
Product information "Anti-phospho-Tau, (Ser396) (PHF13)"
Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5 (1-2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies (1,3). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000. Incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4ºC with gentle shaking, overnight., Optimal dilution determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: United States Biological
Supplier-Nr: T1040-02G

Properties

Application: WB
Antibody Type: Monoclonal
Clone: 9B149(PHF13)
Conjugate: No
Host: Mouse
Reactivity: Human, Mouse, Rat
Immunogen: Human purified Tau (Hoffmann et al., 1997).
Purity: Ascites
Format: Ascites

Database Information

Handling & Safety

Storage: -20°C (-20°C Glycerol)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-phospho-Tau, (Ser396) (PHF13)"
Write a review
or to review a product.
Information about the product reference will follow. more
Viewed