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Anti-phospho-RPA32 (Ser33)

Anti-phospho-RPA32 (Ser33)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A300-246A-T 20 µl (2 blots) -

3 - 9 business days

125.00€
A300-246A-M 100 µl (10 blots) -

3 - 9 business days

303.00€
A300-246A 100 µl (100 µg) -

3 - 9 business days

459.00€
 
Protein function: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds... more
Product information "Anti-phospho-RPA32 (Ser33)"
Protein function: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. [The UniProt Consortium]
Keywords: Anti-phospho-RPA2, Anti-phospho-REPA2, Anti-phospho-RP-A p34, Anti-phospho-RP-A p32, Anti-phospho-RF-A protein 2, Anti-phospho-Replication factor A protein 2, Anti-phospho-Replication protein A 32 kDa subunit
Supplier: Bethyl Laboratories
Supplier-Nr: A300-246A-T

Properties

Application: WB, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan)
Immunogen: synthetic peptide. Immunogen was a phosphorylated synthetic peptide, which represented a portion of human replication protein A2, 32 kDa surrounding phosphorylated serine that corresponded to position 33 using the numbering given in entry NP_002937.1 (GeneID 6118).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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