Anti-phospho-RELA (Ser536) (RELA, NFKB3, Transcription factor p65, Nuclear factor NF-kappa-B p65 sub

Anti-phospho-RELA (Ser536) (RELA, NFKB3, Transcription factor p65, Nuclear factor NF-kappa-B p65 sub
Item number Size Datasheet Manual SDS Delivery time Quantity Price
040951.200 200 µl - -

1 - 19 business days

557.00€
 
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758)... more
Product information "Anti-phospho-RELA (Ser536) (RELA, NFKB3, Transcription factor p65, Nuclear factor NF-kappa-B p65 sub"
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine). Applications: Suitable for use in Dot Blot, ELISA, Recommended Dilution: ELISA: 1:1,000, Dot blot 1:500, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-phospho-RELA, Anti-phospho-NFKB3, Anti-phospho-Transcription factor p65, Anti-phospho-Nuclear factor NF-kappa-B p65 subunit, Anti-phospho-Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
Supplier: United States Biological
Supplier-Nr: 040951

Properties

Application: ELISA, Dot Blot
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: RELA Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S536 of human RELA.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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