Anti-phospho-RELA (Ser536) (RELA, NFKB3, Transcription factor p65, Nuclear factor NF-kappa-B p65 sub

Anti-phospho-RELA (Ser536) (RELA, NFKB3, Transcription factor p65, Nuclear factor NF-kappa-B p65 sub
Item number Size Datasheet Manual SDS Delivery time Quantity Price
040951-APC.200 200 µl - -

3 - 19 business days*

993.00€
 
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758)... more
Product information "Anti-phospho-RELA (Ser536) (RELA, NFKB3, Transcription factor p65, Nuclear factor NF-kappa-B p65 sub"
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine). Applications: Suitable for use in Dot Blot, FLISA, Recommended Dilution: FLISA: 1:1,000, Dot blot 1:500, Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap., , Note: Applications are based on unconjugated antibody.
Keywords: Anti-phospho-RELA, Anti-phospho-NFKB3, Anti-phospho-Transcription factor p65, Anti-phospho-Nuclear factor NF-kappa-B p65 subunit, Anti-phospho-Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
Supplier: United States Biological
Supplier-Nr: 040951-APC

Properties

Application: FLISA, Dot Blot
Antibody Type: Polyclonal
Conjugate: APC
Host: Rabbit
Species reactivity: human
Immunogen: RELA Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S536 of human RELA.
Format: Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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