Product information "Anti-phospho-RanBP3, (Ser58) (Ran-binding Protein 3)"
Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. [The UniProt Consortium]
Anti-phospho-RanBP3, Anti-phospho-RANBP3, Anti-phospho-Ran-binding protein 3
Synthetic peptide corresponding to residues surrounding Ser58 of human RanBP3b.