Anti-PAK4/5/6 (pS474/pS560/pS602), clone ADFF-16

Anti-PAK4/5/6 (pS474/pS560/pS602), clone ADFF-16
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-RQ4826 100 µl - -

3 - 10 business days*

755.00€
 
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. PAK proteins, a... more
Product information "Anti-PAK4/5/6 (pS474/pS560/pS602), clone ADFF-16"
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. Protein function: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell- cycle regulatory protein CDKN1A and by phosphorylating RAN. [The UniProt Consortium]
Keywords: Anti-PAK4, Anti-PAK-4, Anti-KIAA1142, EC=2.7.11.1, Anti-p21-activated kinase 4, Anti-Serine/threonine-protein kinase PAK 4, PAK4/5/6 Antibody (pS474/pS560/pS602)
Supplier: NSJ Bioreagents
Supplier-Nr: RQ4826

Properties

Application: WB
Antibody Type: Monoclonal
Clone: ADFF-16
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A synthetic peptide specific to human PAK4/5/6 (surrounding PAK4-pS474/PAK5-pS560/PAK6-pS602)
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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