Anti-phospho-MYC(Ser62)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-68078.60 60 µl - -

7 - 16 business days*

181.00€
E-AB-68078.120 120 µl - -

7 - 16 business days*

287.00€
E-AB-68078.200 200 µl - -

7 - 16 business days*

469.00€
 
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role... more
Product information "Anti-phospho-MYC(Ser62)"
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. Protein function: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release. [The UniProt Consortium]
Keywords: Anti-phospho-MYC, Anti-phospho-bHLHe39, Anti-phospho-BHLHE39, Anti-phospho-Proto-oncogene c-Myc, Anti-phospho-Transcription factor p64, Anti-phospho-Myc proto-oncogene protein, Anti-phospho-Class E basic helix-loop-helix protein 39, Phospho-MYC(S62) Polyc
Supplier: Elabscience
Supplier-Nr: E-AB-68078

Properties

Application: IHC, IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: A phospho specific peptide corresponding to residues surrounding S62 of human MYC

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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