Anti-phospho-Lats2, CT (Lats2, Serine/threonine-protein kinase LATS2, Kinase during mitosis protein,

Anti-phospho-Lats2, CT (Lats2, Serine/threonine-protein kinase LATS2, Kinase during mitosis protein,
Item number Size Datasheet Manual SDS Delivery time Quantity Price
037693-HRP.200 200 µl - -

3 - 19 business days*

993.00€
 
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size... more
Product information "Anti-phospho-Lats2, CT (Lats2, Serine/threonine-protein kinase LATS2, Kinase during mitosis protein,"
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor (By similarity). Applications: Suitable for use in Western Blot, ELISA, Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:100-500, Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. , , Note: Applications are based on unconjugated antibody.
Keywords: Anti-phospho-Lats2, EC=2.7.11.1, Anti-phospho-Large tumor suppressor homolog 2, Anti-phospho-Serine/threonine-protein kinase kpm, Anti-phospho-Serine/threonine-protein kinase LATS2, Anti-phospho-Kinase phosphorylated during mitosis protein
Supplier: United States Biological
Supplier-Nr: 037693-HRP

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: HRP
Host: Rabbit
Species reactivity: mouse
Immunogen: Mouse Lats2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 999-1027 amino acids from the C-terminal region of mouse Lats2.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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