Anti-phospho-Lats2, CT (Lats2, Serine/threonine-protein kinase LATS2, Kinase during mitosis protein,

Anti-phospho-Lats2, CT (Lats2, Serine/threonine-protein kinase LATS2, Kinase during mitosis protein,
Item number Size Datasheet Manual SDS Delivery time Quantity Price
037693-APC.200 200 µl - -

3 - 19 business days*

993.00€
 
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size... more
Product information "Anti-phospho-Lats2, CT (Lats2, Serine/threonine-protein kinase LATS2, Kinase during mitosis protein,"
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor (By similarity). Applications: Suitable for use in Western Blot, FLISA, Recommended Dilution: FLISA: 1:1,000, Western Blot: 1:100-500, Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap., , Note: Applications are based on unconjugated antibody.
Keywords: Anti-phospho-Lats2, EC=2.7.11.1, Anti-phospho-Large tumor suppressor homolog 2, Anti-phospho-Serine/threonine-protein kinase kpm, Anti-phospho-Serine/threonine-protein kinase LATS2, Anti-phospho-Kinase phosphorylated during mitosis protein
Supplier: United States Biological
Supplier-Nr: 037693-APC

Properties

Application: FLISA, WB
Antibody Type: Polyclonal
Conjugate: APC
Host: Rabbit
Species reactivity: mouse
Immunogen: Mouse Lats2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 999-1027 amino acids from the C-terminal region of mouse Lats2.
Format: Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-phospho-Lats2, CT (Lats2, Serine/threonine-protein kinase LATS2, Kinase during mitosis protein,"
Write a review
or to review a product.
Viewed