Anti-phospho-LATS1/2 (Thr1079/1041)

Anti-phospho-LATS1/2 (Thr1079/1041)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABD-8A8125.50 50 µg - -

2 - 8 business days

228.00€
 
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size... more
Product information "Anti-phospho-LATS1/2 (Thr1079/1041)"
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.
Keywords: Anti-phospho-WARTS, Anti-phospho-LATS1, Anti-phospho-h-warts, EC=2.7.11.1, Anti-phospho-WARTS protein kinase, Anti-phospho-Large tumor suppressor homolog 1, Anti-phospho-Serine/threonine-protein kinase LATS1
Supplier: AAT Bioquest
Supplier-Nr: 8A8125

Properties

Application: IHC, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: synthetic phospho-peptide
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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