Anti-phospho-FGFR1 (Tyr154) (Basic Fibroblast Growth Factor Receptor 1, bFGF-R-1, CD331, FGFBR, FGFR

Anti-phospho-FGFR1 (Tyr154) (Basic Fibroblast Growth Factor Receptor 1, bFGF-R-1, CD331, FGFBR, FGFR
Item number Size Datasheet Manual SDS Delivery time Quantity Price
F4305-02T.50 50 µg - -

3 - 19 business days*

425.00€
 
Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by... more
Product information "Anti-phospho-FGFR1 (Tyr154) (Basic Fibroblast Growth Factor Receptor 1, bFGF-R-1, CD331, FGFBR, FGFR"
Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain. Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues. Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling . The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:40,000, Western Blot: 1:500-1:1000 , Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: EC=2.7.10.1, Anti-phospho-N-sam, Anti-phospho-FLT-2, Anti-phospho-BFGFR, Anti-phospho-Fms-like tyrosine kinase 2, Anti-phospho-Fibroblast growth factor receptor 1, Anti-phospho-Basic fibroblast growth factor receptor 1
Supplier: United States Biological
Supplier-Nr: F4305-02T

Properties

Application: ELISA, IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Synthetic phosphopeptide corresponding to human FGFR1 around the phosphorylation site of tyrosine 154 (A-P-YP-W-T).
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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