Anti-phospho-EGFR (Tyr1068) (human), Rabbit Monoclonal (RM443)

Anti-phospho-EGFR (Tyr1068) (human), Rabbit Monoclonal (RM443)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
REV-31-1334-00-R100 100 µl - -

3 - 9 business days*

483.00€
 
Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating... more
Product information "Anti-phospho-EGFR (Tyr1068) (human), Rabbit Monoclonal (RM443)"
Protein function: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin- binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704, PubMed:17909029). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance. [The UniProt Consortium]
Keywords: Anti-phospho-ERBB, EC=2.7.10.1, Anti-phospho-Proto-oncogene c-ErbB-1, Anti-phospho-Epidermal growth factor receptor, Anti-phospho-Receptor tyrosine-protein kinase erbB-1, anti-EGFR (phospho Y1068) (human), Rabbit Monoclonal (RM443), Anti-Phospho-EGFR (Tyr
Supplier: RevMAb Biosciences
Supplier-Nr: 31-1334-00

Properties

Application: WB
Antibody Type: Monoclonal
Clone: RM443
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: phospho-peptide corresponding to human Phospho- EGFR (Tyr1068)
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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