Anti-phospho-Chk1, (Ser280) (CHEK1, Cell Cycle Checkpoint Kinase)

Anti-phospho-Chk1, (Ser280) (CHEK1, Cell Cycle Checkpoint Kinase)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
C4200-15T.40 40 µg - -

3 - 19 business days*

346.00€
 
Chk1 is a serine/threonine kinase first identified as a checkpoint kinase in Schizosaccharomyces... more
Product information "Anti-phospho-Chk1, (Ser280) (CHEK1, Cell Cycle Checkpoint Kinase)"
Chk1 is a serine/threonine kinase first identified as a checkpoint kinase in Schizosaccharomyces pombe. Chk1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress. Chk1 is activated through phosphorylation by ATR/ATM and plays an important role in DNA damage checkpoint control, embryonic development, and tumor suppression. The activation of Chk1 in response to DNA replication blockages and certain forms of genotoxic stress involves phosphorylation of Ser317 and Ser345°Chk1 is also phosphorylated at Ser280 and Ser296 following DNA damage. Activated Chk1 further activates downstream factors that mediate cell cycle arrest and other cell physiological events through phosphorylation. These key cell cycle factors include p53°Cdc25C and more. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 0.05-0.2ug/ml , Western Blot: 0.5-2ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: EC=2.7.11.1, Anti-phospho-Checkpoint kinase-1, Anti-phospho-CHK1 checkpoint homolog, Anti-phospho-Cell cycle checkpoint kinase, Anti-phospho-Serine/threonine-protein kinase Chk1
Supplier: United States Biological
Supplier-Nr: C4200-15T

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide derived from the residues surrounding Ser 280 of human Chk1 (Swiss Prot: O14757).
Purity: Purified by Protein A affinity chromatography.
Format: Affinity Purified

Handling & Safety

Storage: -20°C (-20°C Glycerol)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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