Anti-phospho-CDKN2A (Ser8)

Anti-phospho-CDKN2A (Ser8)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F48749-0.08ML 80 µl - -

3 - 10 business days*

326.00€
NSJ-F48749-0.4ML 400 µl - -

3 - 10 business days*

702.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene generates several transcript variants which... more
Product information "Anti-phospho-CDKN2A (Ser8)"
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene, this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. Protein function: Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. [The UniProt Consortium]
Keywords: Anti-phospho-MTS-1, Anti-phospho-CDKN2, Anti-phospho-CDK4I, Anti-phospho-p16-INK4, Anti-phospho-p16INK4A, Anti-phospho-p16-INK4a, Anti-phospho-Multiple tumor suppressor 1, Anti-phospho-Cyclin-dependent kinase inhibitor 2A, Phospho-CDKN2A Antibody (pS8)
Supplier: NSJ Bioreagents
Supplier-Nr: F48749

Properties

Application: DB, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS8 of human CDKN2A.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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