Anti-phospho-Catenin, delta 1, (Tyr228)

Anti-phospho-Catenin, delta 1, (Tyr228)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
C2069-54M.100 100 µl - -

3 - 19 business days

554.00€
 
Catenin delta-1 (p120 catenin) has an amino- terminal coiled-coil domain followed by a regulatory... more
Product information "Anti-phospho-Catenin, delta 1, (Tyr228)"
Catenin delta-1 (p120 catenin) has an amino- terminal coiled-coil domain followed by a regulatory domain containing multiple phosphorylation sites and a central Armadillo repeat domain of ten, linked 42 amino-acid repeats. The carboxy-terminal tail has no known function (1). Catenin delta-1 fulfills critical roles in the regulation of cell-cell adhesion as it regulates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion (2). Catenin delta-1 has both positive and negative effects on cadherin-mediated adhesion (3). Actin dynamics are also regulated by catenin delta-1, which modulates RhoA, Rac and cdc42 proteins (1). Analogous to beta-catenin, catenin delta-1 translocates to the nucleus although its role at this location is unclear. Many studies show that catenin delta-1 is expressed irregularly or is absent in various types of tumor cells, suggesting that catenin delta-1 may function as a tumor suppressor (4). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000, Immunofluorescence (IF-IC): 1:100, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplier: United States Biological
Supplier-Nr: C2069-54M

Properties

Application: IF, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic phosphopeptides (KLH-coupled) corresponding to residues surrounding Tyr228 of human/mouse catenin delta-1.
Purity: Purified by peptide affinity chromatography.
Format: Affinity Purified

Database Information

Handling & Safety

Storage: -20°C (-20°C Glycerol)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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