Anti-phospho-Aquaporin 2 (Ser269)

Anti-Aquaporin 2 pS269 Antibody is directed against rat Aquaporin 2 proteins phosphorylated at S269. The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. Minimal reactivity occurs against non-phosphorylated Aquaporin 2. Reactivity against Aquaporin 2 occurs from rat sources. However, reactivity is also expected against the following species based on 100% sequence homology: bovine, canine and mouse. Protein function: Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. [The UniProt Consortium]