Anti-phospho-AKT1 (Thr450) (AKT1, PKB, RAC, RAC-alpha serine/threonine-protein kinase, Protein kinas

Anti-phospho-AKT1 (Thr450) (AKT1, PKB, RAC, RAC-alpha serine/threonine-protein kinase, Protein kinas
Item number Size Datasheet Manual SDS Delivery time Quantity Price
031755-Biotin.200 200 µl - -

3 - 19 business days*

993.00€
 
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in... more
Product information "Anti-phospho-AKT1 (Thr450) (AKT1, PKB, RAC, RAC-alpha serine/threonine-protein kinase, Protein kinas"
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]. Applications: Suitable for use in Dot Blot, ELISA, Recommended Dilution: ELISA: 1:1,000, Dot blot 1:100-500, Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap., , Note: Applications are based on unconjugated antibody.
Keywords: Anti-phospho-PKB, Anti-phospho-AKT1, Anti-phospho-PKB alpha, EC=2.7.11.1, Anti-phospho-RAC-PK-alpha, Anti-phospho-Protein kinase B, Anti-phospho-Proto-oncogene c-Akt, Anti-phospho-Protein kinase B alpha
Supplier: United States Biological
Supplier-Nr: 031755-Biotin

Properties

Application: ELISA, Dot Blot
Antibody Type: Polyclonal
Conjugate: Biotin
Host: Rabbit
Species reactivity: human
Immunogen: Phospho-AKT1-T450 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide surrounding T450 of human AKT1.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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