Anti-phospho-ACTH (Ser168) (POMC, Pro-opiomelanocortin, Corticotropin-lipotropin, NPP, Melanotropin

Anti-phospho-ACTH (Ser168) (POMC, Pro-opiomelanocortin, Corticotropin-lipotropin, NPP, Melanotropin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
031571-HRP.200 200 µl - -

3 - 19 business days*

993.00€
 
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific,... more
Product information "Anti-phospho-ACTH (Ser168) (POMC, Pro-opiomelanocortin, Corticotropin-lipotropin, NPP, Melanotropin"
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used, adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq]. Applications: Suitable for use in Dot Blot, ELISA, Recommended Dilution: ELISA: 1:1,000, Dot blot 1:100-500, Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. , , Note: Applications are based on unconjugated antibody.
Keywords: Anti-phospho-POMC
Supplier: United States Biological
Supplier-Nr: 031571-HRP

Properties

Application: ELISA, Dot Blot
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Phospho-ACTH-pS168 Antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected surrounding S168 of human ACTH.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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