Anti-Histone H3 (Citrullinated Arg2 + Arg8 + Arg17)

Anti-Histone H3 (Citrullinated Arg2 + Arg8 + Arg17)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay17939-100 100 µg -

1 - 10 business days

412.00€
 
Histones are nuclear proteins that are responsible for the nucleosome structure of the... more
Product information "Anti-Histone H3 (Citrullinated Arg2 + Arg8 + Arg17)"
Histones are nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. The basic structure is a 146 bp strand of DNA wrapped around a histone octamer containing pairs of the four core histones (H2A, H2B, H3, and H4). Histones are subjected to numerous post-translational modifications including citrullination (de-imination). Citrullination is necessary for the development of neutrophil extracellular traps (NETs) (hyper-citrullination of histones by PAD4). NETs are a part of the inflammatory response, and neutrophils use NETs to trap and eradicate bacteria and fungi. Failure to clear citrullinated proteins and NET components following inflammation can result in the production of autoantibodies and anti-citrullinated protein antibodies. The persistence of these antibodies and citrullinated proteins is associated with a number of human diseases including rheumatoid arthritis, systemic lupus erythematosus, Alzheimer's disease, and multiple sclerosis. The ability to effectively detect the presence of citrullinated proteins is difficult and presents a barrier to further the understanding of these pathologies. Cayman's Histone H3 (Citrullinated R2 + R8 + R17) Monoclonal Antibody detects citrullinated human H3 by western blot, and does not detect unmodified H3.
Keywords: Anti-citrullinated-H3FH (Citrullinated R2 + R8 + R17), Anti-citrullinated-H3FK, Anti-citrullinated-H3FI, Anti-citrullinated-H3FD, Anti-citrullinated-H3FF, Anti-citrullinated-H3FB, Anti-citrullinated-H3FJ, Anti-citrullinated-H3FA, Anti-citrullinated-H3FL,
Supplier: Cayman Chemical
Supplier-Nr: 17939-100

Properties

Application: ELISA, WB
Antibody Type: Monoclonal
Clone: 11D3
Host: Mouse
Reactivity: Human
Immunogen: Histone 3 peptide with citrullinations at R2, R8, and R17
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H319
P Phrases: P264, P280, P305+P351+P338, P332+P313, P337+P313
Caution
Our products are for laboratory research use only: Not for administration to humans!
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