Anti-acetyl-alpha-Tubulin, clone TEU318

Anti-acetyl-alpha-Tubulin, clone TEU318
Item number Size Datasheet Manual SDS Delivery time Quantity Price
AG-20B-0068-C100 100 µg -

3 - 9 business days

352.00€
 
Detects K40 acetylation of alpha-tubulin, signal specifically increased by modification with... more
Product information "Anti-acetyl-alpha-Tubulin, clone TEU318"
Detects K40 acetylation of alpha-tubulin, signal specifically increased by modification with tubulin acetyl transferase alpha-TAT1. Microtubules are key elements of the eukaryotic cytoskeleton that dynamically assemble from heterodimers of alpha- and beta-tubulin. Two different mechanisms can generate microtubule diversity: the expression of different alpha- and beta-tubulin genes, referred to as tubulin isotypes, and the generation of posttranslational modifications (PTMs) on alpha- and beta-tubulin. Tubulin PTMs include the well-known acetylation or phosphorylation, and others that have so far mostly been found on tubulin, detyrosination/tyrosination, polyglutamylation and polyglycylation. These PTMs might have evolved to specifically regulate tubulin and microtubule functions. Tubulin acetylation was discovered on K40 of flagellar alpha-tubulin in Chlamydomonas reinhardtii and is generally enriched on stable microtubules in cells. It is located on the microtubule lumenal surface. As a result of its localization at the inner face of microtubules, K40 acetylation might rather affect the binding of microtubule inner proteins, a poorly characterized family of proteins. Functional experiments in cells have further suggested that K40 acetylation regulates intracellular transport by regulating the traffic of kinesin motors probably by indirect mechanisms. Acetyltransferase alpha-Tat1 (or Mec-17) specifically acetylate alpha-tubulin K40. Acetylation of tubulin by alpha-Tat1 accumulates selectively in stable, long-lived microtubules thus explaining the link between this posttranslational modication and stable microtubules in cells. However, the direct cellular function of K40 acetylation on microtubules is still unclear.
Keywords: Anti-acetyl-Tubulin alpha chain, (acetylated Lys40, K40)
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-20B-0068-C100

Properties

Application: WB, ICC
Antibody Type: Monoclonal
Clone: TEU318
Conjugate: No
Host: Mouse
Reactivity: Broad
Immunogen: Tubulin of the Ciliate Euplotes eluted from the 55kDa band of SDS gel
Purity: >95%
Format: Purified

Database Information

KEGG ID : K07374 | Find alternatives
UniProt ID : Q08114 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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