PHF8 Antibody AbVantage(TM) Pack

PHF8 Antibody AbVantage(TM) Pack
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A310-633A 1 pack -

3 - 9 business days

617.00€
 
Protein function: Histone lysine demethylase with selectivity for the di- and monomethyl states... more
Product information "PHF8 Antibody AbVantage(TM) Pack"
Protein function: Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. [The UniProt Consortium]
Keywords: Anti-PHF8, Anti-KIAA1111, EC=1.14.11.27, Anti-PHD finger protein 8, Anti-Histone lysine demethylase PHF8
Supplier: Bethyl Laboratories
Supplier-Nr: A310-633A

Properties

Application: WB, IP, IHC, ChIP-Seq
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: synthetic peptide
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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