LATS1 Antibody AbVantage(TM) Pack

LATS1 Antibody AbVantage(TM) Pack
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A310-137A 1 pack -

3 - 9 business days

598.00€
 
Protein function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal... more
Product information "LATS1 Antibody AbVantage(TM) Pack"
Protein function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. [The UniProt Consortium]
Keywords: Anti-h-warts, EC=2.7.11.1, Anti-WARTS protein kinase, Anti-Large tumor suppressor homolog 1, Anti-Serine/threonine-protein kinase LATS1
Supplier: Bethyl Laboratories
Supplier-Nr: A310-137A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human, Mouse
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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