Anti-ZRANB3

Anti-ZRANB3
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-033A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A303-033A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A303-033A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: DNA annealing helicase and endonuclease required to maintain genome stability... more
Product information "Anti-ZRANB3"
Protein function: DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events (PubMed:21078962, PubMed:22704558, PubMed:22705370, PubMed:22759634, PubMed:26884333). Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PubMed:22759634). In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks (PubMed:22705370, PubMed:22704558). [The UniProt Consortium]
Keywords: Anti-AH2, Anti-Endonuclease ZRANB3, Anti-Annealing helicase 2, Anti-DNA annealing helicase ZRANB3, Anti-DNA annealing helicase and endonuclease ZRANB3, Anti-Zinc finger Ran-binding domain-containing protein 3
Supplier: Bethyl Laboratories
Supplier-Nr: A303-033A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Rabbit, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Crab-eating Macaque, Thirteen-lined Ground Squirrel, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A303-033A-T maps to a region between residue 1029 and 1079 of human Zinc Finger, RAN-binding Domain Containing 3 using the numbering given in entry NP_115519.2 (GeneID 84083).
Format: Antigen Affinity Purified

Database Information

UniProt ID : Q5FWF4 | Find alternatives
Gene ID GeneID 84083 | Find alternatives

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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