Anti-ZFYVE19

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-53235.20 20 µl -

7 - 16 business days*

71.00€
E-AB-53235.60 60 µl -

7 - 16 business days*

143.00€
E-AB-53235.120 120 µl -

7 - 16 business days*

238.00€
E-AB-53235.200 200 µl -

7 - 16 business days*

396.00€
 
ZFYVE19 (zinc finger, FYVE domain containing 19), also known as MPFYVE (MLL partner containing... more
Product information "Anti-ZFYVE19"
ZFYVE19 (zinc finger, FYVE domain containing 19), also known as MPFYVE (MLL partner containing FYVE domain), is a 471 amino acid protein that contains one FYVE-type zinc finger. Expressed in heart, brain, kidney, skeletal muscle and liver, ZFYVE19 may participate in transcriptional regulation events within the cell. Defects in the gene encoding ZFYVE19 are associated with acute myeloblastic leukemia (AML), a rapidly progressing cancer of the myeloid line of white blood cells that is characterized by fever, anemia, bone pain, shortness of breath and frequent infections. Three isoforms of ZFYVE19 exist due to alternative splicing events. Protein function: Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission. [The UniProt Consortium]
Keywords: Anti-ANCHR, Anti-ZFYVE19, Anti-MLL partner containing FYVE domain, Anti-Abscission/NoCut checkpoint regulator, Anti-Zinc finger FYVE domain-containing protein 19, ZFYVE19 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-53235

Properties

Application: WB, IHC, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Synthetic peptide of human ZFYVE19

Database Information

UniProt ID : Q96K21 | Matching products
Gene ID GeneID 84936 | Matching products

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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