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Protein function: Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission. [The UniProt Consortium]
Human (Expected: Gorilla, Chimpanzee, Northern White-cheeked Gibbon)
Immunogen:
synthetic peptide. The epitope recognized by A301-808A-T maps to a region between residue 425 and 471 of human zinc finger, FYVE domain containing 19 using the numbering given in entry NP_001070736.1 (GeneID 84936).
