Anti-XPOT

Anti-XPOT
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-63616.60 60 µl -

7 - 16 business days*

198.00€
E-AB-63616.120 120 µl -

7 - 16 business days*

317.00€
E-AB-63616.200 200 µl -

7 - 16 business days*

525.00€
 
This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of... more
Product information "Anti-XPOT"
This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. Protein function: Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP- bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [The UniProt Consortium]
Keywords: Anti-XPOT, Anti-Exportin-T, Anti-tRNA exportin, Anti-Exportin(tRNA), XPOT Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-63616

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Recombinant protein of human XPOT

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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