Anti-X-box Binding Protein 1 (XBP1)

Anti-X-box Binding Protein 1 (XBP1)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
X0989-51B.50 50 µg - -

1 - 19 business days

650.00€
 
This protein is a transcription factor that regulates MHC class II genes by binding to a promoter... more
Product information "Anti-X-box Binding Protein 1 (XBP1)"
This protein is a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. The protein contains two domains commonly found in transcription factors that confer DNA binding and dimerization capability. This gene product was also separately identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. There is also a recent finding that the same agents that cause an ER stress response, the unfolded protein response, also increase transcription of this gene. This increase in transcription requires an ER stress response consensus binding element in the promoter. Adding to the list of functional possibilities is a recent report from studies of knockout mice showing that this gene is essential for hepatocyte growth. A pseudogene has been identified and localized to chromosome 5. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: 20ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: Anti-TREB5, Anti-XBP-1, Anti-X-box-binding protein 1, Anti-Tax-responsive element-binding protein 5
Supplier: United States Biological
Supplier-Nr: X0989-51B

Properties

Application: IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide, KLH-conjugated. Epitope: 18 amino acid peptide from near the amino terminus of human XBP-1

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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