Anti-WDR4

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-18304.20 20 µl -

7 - 16 business days*

71.00€
E-AB-18304.60 60 µl -

7 - 16 business days*

143.00€
E-AB-18304.120 120 µl -

7 - 16 business days*

238.00€
E-AB-18304.200 200 µl -

7 - 16 business days*

396.00€
 
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved... more
Product information "Anti-WDR4"
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Protein function: Non-catalytic component of a methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031084, PubMed:31031083). In the methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit (PubMed:12403464). Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (PubMed:12403464, PubMed:31031084). Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs (PubMed:31031084). Also required for methylation of a specific subset of miRNAs, such as let-7 (PubMed:31031083). Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 (PubMed:26751069). [The UniProt Consortium]
Keywords: Anti-hWH, Anti-Protein Wuho homolog, Anti-WD repeat-containing protein 4, Anti-tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4, WDR4 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-18304

Properties

Application: WB, IHC, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse
Immunogen: Fusion protein of human WDR4

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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