Anti-WDFY3 (IHC)

Anti-WDFY3 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00372-T 10 µl (5+ slides) -

3 - 9 business days*

IHC-00372 100 µl (50+ slides) -

3 - 9 business days*

Protein function: Required for selective macroautophagy (aggrephagy). Acts as an adapter protein... more
Product information "Anti-WDFY3 (IHC)"
Protein function: Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PubMed:20417604). Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin- containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin- 1/NTN1. Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (PubMed:27008544). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway. After cytokinetic abscission, involved in midbody remnant degradation (PubMed:24128730). In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:15292400). [The UniProt Consortium]
Keywords: Anti-Alfy, Anti-WDFY3, Anti-KIAA0993, Anti-Autophagy-linked FYVE protein, Anti-WD repeat and FYVE domain-containing protein 3
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00372


Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Bovine, Dog, Swine, Orangutan, Gorilla, Chimpanzee, White-tufted-ear Marmoset, European Domestic Ferret, Little Brown Bat, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by IHC-00372 maps to a region between residue 500 and 550 of human WD repeat and FYVE domain containing 3 using the numbering given in entry NP_055806.2 (GeneID 23001).
Format: Antigen Affinity Purified

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Storage: +4°C
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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