Anti-VDAC1 (Voltage-Dependent Anion Channel 1, Mitochondrial Porin, Outer Mitochondrial Membrane Pro

Anti-VDAC1 (Voltage-Dependent Anion Channel 1, Mitochondrial Porin, Outer Mitochondrial Membrane Pro
Item number Size Datasheet Manual SDS Delivery time Quantity Price
V2121-20A.50 50 µg - -

4 - 22 business days

650.00€
 
VDAC (also known as Voltage-dependent anion-selective channel protein 1, Outer mitochondrial... more
Product information "Anti-VDAC1 (Voltage-Dependent Anion Channel 1, Mitochondrial Porin, Outer Mitochondrial Membrane Pro"
VDAC (also known as Voltage-dependent anion-selective channel protein 1, Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL) is an outer membrane mitochondrial protein. The VDAC proteins are ~30-33 kDa (some isoforms are larger-see below). The VDAC proteins are thought to form aqueous channels, or pores, through which adenine nucleotides cross the outer mito-chondrial membrane. VDACs have been implicated in the formation of the mitochondrial permeability transition pore complex in apoptotic cells. This complex, formed by VDAC, adenine nucleotide translocator (ANT), and cyclophilin D (CypD), is thought to allow the mitochondria to undergo metabolic uncoupling and irreversible morphologic changes that ultimately destroy the mitochondria during apoptosis. VDACs are highly expressed in heart, liver and skeletal muscle, where concentrations of mitochondria are at their highest. This antibody can be used as a loading control with whole cell lysates and total mitochondrial preparations. Applications: Suitable for use in ELISA, Immunofluorescence, Western Blot and Immunohistochemistry. Other applications have not been tested. Recommended Dilutions: Immunohistochemistry (FFPE): 2.5ug/ml. Heat-induced antigen retrieval using citrate buffer, pH 6.0 is recommended., Western Blot: 1:500-1:2000, ELISA: 1:10,000-1:40,000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-hVDAC1, Anti-VDAC-1, Anti-Porin 31HM, Anti-Plasmalemmal porin, Anti-Outer mitochondrial membrane protein porin 1, Anti-Voltage-dependent anion-selective channel protein 1
Supplier: United States Biological
Supplier-Nr: V2121-20A

Properties

Application: ELISA, IF, IHC, WB
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide, KLH-conjugated. Epitope: Amino acids 185-197 of Human VDAC1/Porin1.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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