Anti-VCAM-1

Anti-VCAM-1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-RQ4185 100 µg - -

3 - 10 business days*

755.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. CD106 (cluster of differentiation 106)... more
Product information "Anti-VCAM-1"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. CD106 (cluster of differentiation 106) also known as vascular cell adhesion molecule 1 (VCAM-1), is a protein that in humans is encoded by the VCAM1 gene. In inflammatory conditions and in cardiac allografts undergoing rejection, VCAM1 is upregulated in endothelium of postcapillary venules. Arterial expression of VCAM1 is also found in experimental models of atherosclerosis in the rabbit. This gene is mapped to chromosome 1 by Southern analysis of somatic cell hybrids. VCAM-1 functions as a cell adhesion molecule. The VCAM-1 protein mediates the adhesion of lymphocytes, monocytes, eosinophils, andbasophils to vascularendothelium. It also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development ofatherosclerosis and rheumatoid arthritis. CAM741 works similar to cotransin in that it represses the biosynthesis of VCAM1 cells by blocking the process of cotranslational translocation, which is dependent on the signal peptide of VCAM1. Among the lung metastasis signature genes identified, several, including VCAM1, were functionally validated. Protein function: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. [The UniProt Consortium]
Keywords: Anti-VCAM1, Anti-CD106, Anti-VCAM-1, Anti-V-CAM 1, Anti-INCAM-100, Anti-Vascular cell adhesion protein 1, VCAM-1 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: RQ4185

Properties

Application: WB, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A recombinant human protein corresponding to amino acids F25-L270 was used as the immunogen for the VCAM1 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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