Anti-Vanilloid Receptor 1 (Capsaicin receptor, DKFZp434K0220, osm 9 like TRP channel 1, OTRPC1, TRPV

Anti-Vanilloid Receptor 1 (Capsaicin receptor, DKFZp434K0220, osm 9 like TRP channel 1, OTRPC1, TRPV
Item number Size Datasheet Manual SDS Delivery time Quantity Price
C1078-10B.100 100 µg - -

3 - 19 business days*

503.00€
 
The capsaicin receptor is involved in the detection of noxious chemical and thermal stimuli. It... more
Product information "Anti-Vanilloid Receptor 1 (Capsaicin receptor, DKFZp434K0220, osm 9 like TRP channel 1, OTRPC1, TRPV"
The capsaicin receptor is involved in the detection of noxious chemical and thermal stimuli. It seems to mediate proton influx and to be involved in intracellular acidosis in nociceptive neurons. It may also mediate inflammatory pain and hyperalgesia. It is activated by vanilloids, such as capsaicin, and temperatures higher than 42ºC. The capsaicin receptor is probably as homotetramer but may also form a heteromeric channel with TRPV3. It interacts with calmodulin, PRKCM and CSK and with PRKCG and NTRK1. There are 3 named isoforms produced by alternative splicing. The capsaicin receptor is a transmembrane protein that localises to the cell membrane. It is predominantly expressed in trigeminal and dorsal root sensory ganglia. Isoform 1 and 3 are also expressed in brain and peripheral blood mononuclear cells. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilutions: ELISA: 1:100,000, Western Blot: 1:5000, detects the 95kD Vanilloid Receptor 1 in mouse brain tissue extract. , Optimal dilutions to be determined by researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute by adding sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20°C Aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer., ,
Keywords: Anti-Trpv1, Anti-TrpV1, Anti-OTRPC1, Anti-Vanilloid receptor 1, Anti-Osm-9-like TRP channel 1, Anti-Transient receptor potential cation channel subfamily V member 1
Supplier: United States Biological
Supplier-Nr: C1078-10B

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Mouse
Immunogen: Synthetic peptide (GEKPPRLYDRR) corresponding to the aa105-115 of mouse Vanilloid Receptor 1 (KLH).
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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