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Anti-USP33, CT (Ubiquitin Carboxyl-terminal Hydrolase 33, Ubiquitin Thiolesterase 33, Ubiquitin-spec

Anti-USP33, CT (Ubiquitin Carboxyl-terminal Hydrolase 33, Ubiquitin Thiolesterase 33, Ubiquitin-spec
Item number Size Datasheet Manual SDS Delivery time Quantity Price
U4101-35G-HRP.200 200 µl - -

1 - 19 business days

696.00€
 
Type 2 iodothyronine deiodinase (D2) is an integral membrane selenoenzyme that stimulates the... more
Product information "Anti-USP33, CT (Ubiquitin Carboxyl-terminal Hydrolase 33, Ubiquitin Thiolesterase 33, Ubiquitin-spec"
Type 2 iodothyronine deiodinase (D2) is an integral membrane selenoenzyme that stimulates the pro-hormone thyroxine (T4) and supplies the majority of the 3,5,3?-triiodothyronine (T3) essential for brain development. T4 catalysis accelerates selective conjugation to ubiquitin and thereby renders D2 inactive, a posttranslational feedback mechanism used to maintain acceptable T3 levels.2,3 Ub-D2 was the first recognized substrate for von Hippel-Lindau protein-interacting (pVHL-interacting) deubiquitinating enzyme-1 (VDU1). VDU proteins colocalize with D2 in the endoplasmic reticulum, and their coexpression provides D2 resistance to degradation. VDU1 expression is substantially upregulated in brown adipocytes by norepinephrine or cold exposure, further amplifying D2 activity. VDU1 and VDU2 are coexpressed with D2 in many human tissues, including brain, heart, and skeletal muscle, suggesting potential roles in neurological development, cardiac function, and energy management, in addition to thermal homeostasis.VDU1- or VDU2-catalyzed deubiquitination recycles inactive Ub-D2 to its active deubiquitinated form, circumventing the proteasomal degradation pathway. Thus, Ub-D2 can be either reactivated or degraded, with the balance between these two processes influenced by VDU activity.VDU1-catalyzed D2 deubiquitination may be an important participant in the adaptive mechanism that regulates thyroid hormone action. The reversible ubiquitination-dependent mechanism regulating D2 activity permits highly responsive control of thyroid hormone activation.5,6 , Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:1,000, Immunohistochemistry: 1:50-1:100, Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. , , Note: Applications are based on unconjugated antibody.
Keywords: Anti-USP33, Anti-hVDU1, Anti-KIAA1097, EC=3.4.19.12, Anti-Ubiquitin thioesterase 33, Anti-Deubiquitinating enzyme 33, Anti-Ubiquitin carboxyl-terminal hydrolase 33, Anti-Ubiquitin-specific-processing protease 33
Supplier: United States Biological
Supplier-Nr: U4101-35G-HRP

Properties

Application: ELISA, IHC
Antibody Type: Polyclonal
Conjugate: HRP
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide selected from the C-terminal region of human USP33 (KLH).
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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