Anti-USP2, clone 1738CT331.50.87

Anti-USP2, clone 1738CT331.50.87
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F53953-0.05ML 50 µl - -

3 - 10 business days*

326.00€
NSJ-F53953-0.2ML 200 µl - -

3 - 10 business days*

702.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. Ubiquitin carboxyl-terminal hydrolase 2 is a... more
Product information "Anti-USP2, clone 1738CT331.50.87"
In 1X PBS, pH 7.4, with 0.09% sodium azide. Ubiquitin carboxyl-terminal hydrolase 2 is a hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity). Protein function: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 (PubMed:17290220, PubMed:19917254, PubMed:19838211). Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity (PubMed:17290220, PubMed:19838211). Has no deubiquitinase activity against p53/TP53 (PubMed:17290220). Prevents MDM2-mediated degradation of MDM4 (PubMed:17290220). Plays a role in the G1/S cell-cycle progression in normal and cancer cells (PubMed:19917254). Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. [The UniProt Consortium]
Keywords: Anti-USP2, Anti-UBP41, EC=3.4.19.12, Anti-Ubiquitin thioesterase 2, Anti-Deubiquitinating enzyme 2, Anti-41 kDa ubiquitin-specific protease, Anti-Ubiquitin carboxyl-terminal hydrolase 2, Anti-Ubiquitin-specific-processing protease 2, USP2 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: F53953

Properties

Application: WB
Antibody Type: Monoclonal
Clone: 1738CT331.50.87
Conjugate: No
Host: Mouse
Species reactivity: human, african green monkey
Immunogen: A partial recombinant protein corresponding to amino acids 1-258 from the human protein
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-USP2, clone 1738CT331.50.87"
Write a review
or to review a product.
Viewed