Anti-USP13

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-762A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-762A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-762A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Deubiquitinase that mediates deubiquitination of target proteins such as BECN1,... more
Product information "Anti-USP13"
Protein function: Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34- containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro, however, additional experiments are required to confirm such data. [The UniProt Consortium]
Keywords: Anti-USP13, Anti-ISOT3, Anti-ISOT-3, EC=3.4.19.12, Anti-Isopeptidase T-3, Anti-Ubiquitin thioesterase 13, Anti-Deubiquitinating enzyme 13, Anti-Ubiquitin carboxyl-terminal hydrolase 13, Anti-Ubiquitin-specific-processing protease 13
Supplier: Bethyl Laboratories
Supplier-Nr: A302-762A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Bovine)
Immunogen: synthetic peptide. The epitope recognized by A302-762A-T maps to a region between residue 175 and 225 of human Ubiquitin Specific Peptidase 13 using the numbering given in entry NP_003931.2 (GeneID 8975).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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