Anti-Tyrosinase (Melanoma Marker) Recombinant Mouse Monoclonal Antibody (clone:rOCA1/812)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-12-1261-100 100 µg -

3 - 11 business days*

850.00€
 
Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor... more
Product information "Anti-Tyrosinase (Melanoma Marker) Recombinant Mouse Monoclonal Antibody (clone:rOCA1/812)"
Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway, the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants.This MAb is a useful marker for melanocytes and melanomas. Protein function: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4- dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6- dihydroxyindole) to indole-5,6 quinone. [The UniProt Consortium]
Keywords: Anti-TYR, Anti-SK29-AB, Anti-LB24-AB, Anti-Tyrosinase, EC=1.14.18.1, Anti-Monophenol monooxygenase, Anti-Tumor rejection antigen AB, Anti-Tyrosinase (Melanoma Marker) Recombinant Mouse Monoclonal Antibody (Clone:rOCA1/812)
Supplier: Abeomics
Supplier-Nr: 12-1261

Properties

Application: IHC
Antibody Type: Monoclonal
Clone: rOCA1/812
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Recombinant full-length human tyrosinase protein
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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