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Protein function: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. [The UniProt Consortium]
Keywords:
Anti-TTI2, Anti-C8orf41, Anti-TELO2-interacting protein 2
synthetic peptide. The epitope recognized by A303-476A-T maps to a region between residue 458 and 508 of human TELO2 interacting protein 2 using the numbering given in entry NP_079391.2 (GeneID 80185).
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