Anti-Transglutaminase II (TGase II, Transglutaminase 2, TG2, TGase 2, TGase2, TGase-2, TGM2, G Prote

Anti-Transglutaminase II (TGase II, Transglutaminase 2, TG2, TGase 2, TGase2, TGase-2, TGM2, G Prote
Item number Size Datasheet Manual SDS Delivery time Quantity Price
T8260-03H.100 100 µg - -

3 - 19 business days*

629.00€
 
Transglutaminase 2 is historically a member of the transglutaminase family that catalyzes a... more
Product information "Anti-Transglutaminase II (TGase II, Transglutaminase 2, TG2, TGase 2, TGase2, TGase-2, TGM2, G Prote"
Transglutaminase 2 is historically a member of the transglutaminase family that catalyzes a calcium-dependent acyl transfer reaction between peptide bound glutamine and a suitable primary amine.The protein is known to participate in all-trans-retinoic acid mediated signaling events as a G-protein and transamidate targets such as RhoA and the retinoblastoma gene product. The action of transglutaminase 2 stabilizes proteins by conferring mechanical resistance and protection from proteolysis. The protein is expressed intracellularly and secreted on the cell surface where it interacts with proteins in the extracellular matrix and aids in anchoring cells to basement membranes. Recently, transglutaminase 2 has been identified as an important factor that interacts with fibronectin in the extracellular matrix at the cell membrane and provides survival signals and inhibits anoikis in fibroblasts. The protein is expressed in human endothelial cells. The human transglutaminase 2 gene is localized in the chromosomal region 20q12. Transcript variants encoding two different isoforms have been found for this gene. Deficiency of the protein results in early-onset diabetes type 2. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml, Optimal dilutions to be determined by the researcher. Positive Control: BxPC-3 cell lysaste, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: EC=2.3.2.13, Anti-Transglutaminase-2, Anti-Tissue transglutaminase, Anti-Protein-glutamine gamma-glutamyltransferase 2
Supplier: United States Biological
Supplier-Nr: T8260-03H

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Synthetic peptide corresponding to aa600-650 of human Transglutaminase 2.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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