Anti-Transglutaminase 2 (TGM2), clone SPM592

Anti-Transglutaminase 2 (TGM2), clone SPM592
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2891IHC-7ML 7 ml - -

3 - 10 business days

Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*.... more
Product information "Anti-Transglutaminase 2 (TGM2), clone SPM592"
Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*. Recognizes a 77-85kDa protein, identified as cellular or tissue transglutaminase II (TGase II, TGM2). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing. Protein function: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. [The UniProt Consortium]
Keywords: Anti-TGC, Anti-TGM2, Anti-TG(C), Anti-TGase H, Anti-TGase-2, Anti-TGase C, EC=, Anti-Transglutaminase-2, Anti-Transglutaminase C, Anti-Transglutaminase H, Anti-Tissue transglutaminase, Anti-Protein-glutamine gamma-glutamyltransferase 2, Transgluta
Supplier: NSJ Bioreagents
Supplier-Nr: V2891IHC-7ML


Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: SPM592
Conjugate: No
Host: Mouse
Reactivity: Human, Monkey, Rabbit, Mouse, Rat
Immunogen: Recombinant full-length human TGM2 protein
Format: Purified

Handling & Safety

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Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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