Anti-TRAF6

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG54683.50 50 µg - -

6 - 14 business days*

520.00€
 
Protein function: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the... more
Product information "Anti-TRAF6"
Protein function: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c- Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. [The UniProt Consortium]
Keywords: Anti-RNF85, Anti-TRAF6, EC=6.3.2.-, Anti-RING finger protein 85, Anti-Interleukin-1 signal transducer, Anti-TNF receptor-associated factor 6, Anti-E3 ubiquitin-protein ligase TRAF6
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG54683

Properties

Application: ELISA, WB, ICC, IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Stnthetic peptide around 14 aa (C-terminus) of Human TRAF6 protein (NP_004611.1)
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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